Homozygosity mapping of depressive disorder in a large family from Pakistan: Significant linkage on chromosome 6 and 9

Abstract A large family with a high prevalence of recurrent major depression and high average inbreeding coefficient was ascertained from rural Pakistan. Subjects were interviewed and diagnosed by a trained psychiatrist, 370 microsatellite markers were genotyped and the program FEstim was used for homozygosity mapping. Significant linkage was found on Chromosome 9 and Chromosome 6 after fine mapping. These regions on Chromosome 6 and 9 may harbor genes which predispose to depression. © 2012 Wiley Periodicals, Inc. (Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)

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