[Correspondence] A presenilin 1 mutation in the first case of Alzheimer's disease

Auguste Deter is undoubtedly one of the most famous patients in medical history. She was the middle-aged woman in whom Alois Alzheimer first reported on “eine eigenartige Erkrankung der Hirnrinde” (a peculiar disorder of the cerebral cortex) more than a century ago. The patient came to Alzheimer's attention when she was admitted to his psychiatric service at age 51 years, because of substantial forgetfulness accompanied by hallucinations. Dementia progressed rapidly and she died 5 years later, in 1906, at age 56 years. (Source: Lancet Neurology)

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