The Informant Questionnaire on Cognitive Decline in the Elderly Individuals in Screening Mild Cognitive Impairment With or Without Functional Impairment

In this study, we investigate the utility of the IQCODE for patients with mild cognitive impairment (MCI) and the discriminative power of the IQCODE in patients having MCI with and without functional impairment. The samples included mild Alzheimer disease (AD, N = 280), MCI ([N = 657], further divided into 2 subgroups: patients with MCI having functional impairment [MCI-fi, N = 357] and patients having MCI without functional impairment [MCI-fn, N = 300]), and normal cognition (NC, N = 274). The IQCODE, Mini-Mental State Examination (MMSE), and other neuropsychological tests were administered to all participants. Logistic regression and receiver–operating characteristic (ROC) curves were used to evaluate the diagnostic ability of the IQCODE, compared to the MMSE. The optimal cutoff sc...

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